Neuroimmunology and Neuroinflammation
Neuroimmunology is the combination of the neuroscience and immunology studies. A common technique applied to the discovery of novel immune populations in humans and rodents is mass cytometry, or CyTOF (cytometry by time-of-flight). It uses metal-conjugated antibodies to allow for a high-dimensional description at single-cell level of tens of markers, thus providing a bird's-eye view of the immune system. Neuroinflammation is a complex brain injury response involving glia activation, release of inflammatory mediators, such as cytokines and chemokines, and reactive oxygen and nitrogen species production. Inflammatory reactions in the brain are also linked to increased levels of prostaglandins (PGs), especially PGE2. PGE2 signaling is mediated by interactions with four distinct G-protein-coupled receptors, EP1, EP2, EP3, and EP4, which are expressed differently across the central nervous system on neuronal and glial cells. Often present in aged brain are elevated PGE2 and inflammatory mediators.
- Track 1-1 Neuro Immuno Genetics
- Track 2-2 Auto Immune Neuropathies
- Track 3-3 Biomarkers
- Track 4-4 Types of Neurological Infections
- Track 5-5 Role of Infections and inflammation in Neuroimmune Disorders